Molecular Modeling and Chiral Separation of Benzodiazepines by Capillary Electrophoresis Using Highly Sulfated Cyclodextrins
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چکیده
منابع مشابه
Chiral Separation of Basic and Zwitterionic Drugs by Highly Sulfated Cyclodextrins Using Short-End Injection Capillary Electrophoresis Highly Sulfated Cyclodextrins Using Short-End Injection Capillary Electrophoresis
Due to high resolution power of sulfated cyclodextrins (HS-CDs), utilization of these selectors for chiral resolution of 7 basic and 2 zwitterionic drugs have been examined. Experiments were performed on a HP3DCE instrument equipped with an on-column diode array UV absorbance detector. Fused silica capillaries with an inner diameter of 50 ?m, an outer diameter of 365 ?m, and a total length of 4...
متن کاملChiral Separation of Basic and Zwitterionic Drugs by Highly Sulfated Cyclodextrins Using Short-End Injection Capillary Electrophoresis Highly Sulfated Cyclodextrins Using Short-End Injection Capillary Electrophoresis
Due to high resolution power of sulfated cyclodextrins (HS-CDs), utilization of these selectors for chiral resolution of 7 basic and 2 zwitterionic drugs have been examined. Experiments were performed on a HP3DCE instrument equipped with an on-column diode array UV absorbance detector. Fused silica capillaries with an inner diameter of 50 ?m, an outer diameter of 365 ?m, and a total length of 4...
متن کاملchiral separation of basic and zwitterionic drugs by highly sulfated cyclodextrins using short-end injection capillary electrophoresis highly sulfated cyclodextrins using short-end injection capillary electrophoresis
due to high resolution power of sulfated cyclodextrins (hs-cds), utilization of these selectors for chiral resolution of 7 basic and 2 zwitterionic drugs have been examined. experiments were performed on a hp3dce instrument equipped with an on-column diode array uv absorbance detector. fused silica capillaries with an inner diameter of 50 ?m, an outer diameter of 365 ?m, and a total length of 4...
متن کاملCyclodextrine Screening for the Chiral Separation of Carvedilol by Capillary Electrophoresis
Carvedilol is administered as a racemic mixture of the R(+)- and S(-)-enantiomers, although it was demonstrated that the two enantiomers exhibit different pharmacological effects and stereoselective pharmacokinetics. The aim of this study was the evaluation of several native and derivatized cyclodextrines as chiral selectors for the separation of carvedilol enantiomers. Stereoselective interact...
متن کاملMolecular Modeling Study of Chiral Separation and Recognition Mechanism of β-Adrenergic Antagonists by Capillary Electrophoresis
Chiral separations of five β-adrenergic antagonists (propranolol, esmolol, atenolol, metoprolol, and bisoprolol) were studied by capillary electrophoresis using six cyclodextrins (CDs) as the chiral selectors. Carboxymethylated-β-cyclodextrin (CM-β-CD) exhibited a higher enantioselectivity power compared to the other tested CDs. The influences of the concentration of CM-β-CD, buffer pH, buffer ...
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ژورنال
عنوان ژورنال: Journal of the Mexican Chemical Society
سال: 2018
ISSN: 2594-0317,1870-249X
DOI: 10.29356/jmcs.v62i2.413